Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 10 MG

Supplier:  Medchemexpress LLC HY108642B10MM/1ML

AMG-548 dihydrochloride is an orally active and selective p38α inhibitor with a Ki of 0.5 nM. It exhibits slight selectivity over p38β (Ki=36 nM) and a greater than 1000-fold selectivity against p38γ and p38δ. This compound is highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM) and also inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.

• Selective p38α inhibitor (Ki=0.5 nM).
• Slightly selective over p38β (Ki=36 nM).
• Greater than 1000-fold selective against p38γ and p38δ.
• Potent inhibition of whole blood LPS stimulated TNFα (IC50=3 nM).
• Inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.

Catalog No. 50-003-46244