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Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 50 MG
SDP

Catalog No. 5000344272
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AMG-548 dihydrochloride is an orally active and selective inhibitor of p38α (Ki=0.5 nM), showing slight selectivity over p38β (Ki=36 nM) and more than 1000-fold selectivity against p38γ and p38δ. It is also highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM). Additionally, this compound inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.

  • Selective p38α inhibitor with high potency.
  • Potent inhibition of whole blood LPS-stimulated TNFα and IL1β.
  • Inhibits Wnt signaling through direct targeting of Casein kinase 1 isoforms δ and ε.
  • Good oral bioavailability in vivo.

Catalog No. 50-003-44272 Supplier Medchemexpress LLC Supplier No. HY108642B10MG
May include imposed supplier surcharges.
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AMG-548 dihydrochloride is an orally active and selective inhibitor of p38α (Ki=0.5 nM), showing slight selectivity over p38β (Ki=36 nM) and more than 1000-fold selectivity against p38γ and p38δ. It is also highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM). Additionally, this compound inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.

  • Selective p38α inhibitor with high potency.
  • Potent inhibition of whole blood LPS-stimulated TNFα and IL1β.
  • Inhibits Wnt signaling through direct targeting of Casein kinase 1 isoforms δ and ε.
  • Good oral bioavailability in vivo.

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