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Medchemexpress LLC AMG 579 | 1227067-61-9 | 99.0% | 50 MG
Supplier: Medchemexpress LLC HY1291350MG
AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. It is intended for research use only. In vivo, AMG 579 has shown a statistically significant reduction of PCP-induced behavior in rats over a 2-hour period, with a minimum effective dose for efficacy in the PCP-LMA model determined to be 0.3 mg/kg. In dogs, it exhibits a superior oral bioavailability of 72%. One clinical trial (NCT01568203) is listed, sponsored by Amgen for Schizophrenia, with a start date of 2011-09, and it is in Phase 1.
- Potent, selective, and efficacious PDE10A inhibitor
- Demonstrates in vivo efficacy in reducing PCP-induced behavior in rats
- Exhibits superior oral bioavailability in dogs
- Underwent early-phase clinical trials for Schizophrenia
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