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Medchemexpress LLC AMG 837 (calcium hydrate) | 1259389-38-2 | 99.0% | 455.45 | 50 MG
Supplier: Medchemexpress LLC HY13967B50MG
AMG 837 calcium hydrate is a potent, orally bioavailable, and partial agonist of GPR40/FFA1. It is known to enhance insulin secretion and lower glucose levels in rodents. This compound also functions as a click chemistry reagent, featuring an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Potent, orally bioavailable, and partial agonist of GPR40/FFA1
- Inhibits specific binding at human FFA1 receptor with a pIC50 of 8.13
- Enhances insulin secretion and lowers glucose levels in rodents
- Click chemistry reagent with an alkyne group for CuAAc with azide groups
- Stimulates insulin secretion in a glucose-dependent manner (EC50 of 142±20 nM on mouse islets)
- Improves glucose tolerance and enhances insulin secretion in Sprague-Dawley rats
- Displays excellent oral bioavailability (F = 84%) in vivo
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