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Medchemexpress LLC Amg perk 44 | 1883548-84-2 | 99.7% | 100 MG
Supplier: Medchemexpress LLC HY12661A100MG
This compound is an orally active and highly selective inhibitor of PERK, demonstrating potent activity with an IC50 of 6 nM. It exhibits significant selectivity, showing 1000-fold preference over GCN2 and 160-fold over B-Raf. Furthermore, this agent has been shown to induce autophagy.
- Exhibits high potency against its target with a low nanomolar IC50.
- Demonstrates remarkable selectivity compared to other related kinases.
- Induces autophagy, suggesting potential in related cellular processes.
- Effective when administered orally.
- Robustly inhibits target autophosphorylation in living systems.
- Maintains sustained target inhibition in vivo for up to 24 hours at certain dosages.
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