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Apexbio Technology LLC AMI-1 20324-87-2 5mg
Supplier: Apexbio Technology LLC A19085
AMI-1 (CAS 20324-87-2) is a small molecule inhibitor of protein arginine N-methyltransferase 1 (PRMT1) exhibiting an IC50 of 8 8 M It acts by preventing the binding of peptide substrates to PRMT1 without interfering with the S-adenosyl-L-methionine (SAM) cofactor binding site In addition to its action on PRMT1 AMI-1 inhibits HIV-1 reverse transcriptase polymerase activity with an IC50 of 5 0 M AMI-1 is cell-permeable facilitating its use in cellular studies investigating arginine methylation epigenetic regulation and viral replication
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