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Medchemexpress LLC AMI-1 | 20324-87-2 | 98.0% | 548.45 | 25 MG
Supplier: Medchemexpress LLC 25MGHY18962
AMI-1 is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It inhibits PRMTs by blocking peptide-substrate binding.
- Potent, cell-permeable, and reversible inhibitor
- Inhibits in vitro methylation reactions performed by PRMT1, -3, -4, -6, and Hmt1p
- Inhibits both type I and type II PRMTs
- Specifically inhibits arginine methyltransferase activity
- Does not compete for the AdoMet binding site
- Inhibits methylation of GFP-Npl3 and cellular proteins
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