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Medchemexpress LLC AMI-1 free acid | 134-47-4 | 99.5% | 504.49 | 1 ML
Supplier: Medchemexpress LLC HY18962A10MM/1ML
AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It exerts its inhibitory effects on PRMTs by blocking peptide-substrate binding.
- Potent, cell-permeable, and reversible inhibitor of PRMTs.
- Inhibits type I PRMTs and type II PRMT5.
- Specifically inhibits arginine methyltransferase activity, not lysine, and does not compete for the AdoMet binding site.
- Inhibits methylation of GFP-Npl3 and cellular proteins.
- Inhibits the cell viability of sarcoma in S180 and U2OS cells in a time- and dose-dependent manner in vitro.
- Reduces S180 cell viability through the induction of cell apoptosis.
- Inhibits S180 viability in vivo.
- Downregulates PRMT5 and decreases levels of H4R3me2s and H3R8me2s in a tumor xenograft model.
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