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Medchemexpress LLC Amiloride hydrochloride | 2016-88-8 | 99.8% | 1 ML
SDP

Supplier:  Medchemexpress LLC HYB0285A10MM/1ML

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Amiloride hydrochloride is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). It also acts as a blocker of the polycystin-2 (PC2; TRPP2) channel. This compound is suitable for research applications targeting these pathways.

  • Inhibitor of epithelial sodium channel (ENaC)
  • Inhibitor of urokinase-type plasminogen activator receptor (uTPA)
  • Blocker of polycystin-2 (PC2; TRPP2) channel
  • Relatively selective ENaC inhibitor with IC50 ranging from 0.1 to 0.5 μM
  • Demonstrated to reverse initial increases in collagen deposition in DOCA-salt hypertensive rats
  • Delays the onset of proteinuria in stroke-prone spontaneously hypertensive rats (SHRSP)
  • Antagonizes or prevents aldosterone actions in animal models of salt-dependent hypertension

Catalog No. 50-004-05969


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