Sigma Aldrich Amino-Peg4-T-Butyl Ester

Catalog No.	Quantity
90-253-51G	50 mg

Catalog No. 90-253-51G Supplier Sigma Aldrich Supplier No. 9025351G

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC™ molecules) for targeted protein degradation.Real-time monitoring of vesicle pH in an endocytic pathway using an EGF-conjugated two-photon probeDevelopment of Substrate-Selective Probes for Affinity Pulldown of Histone DemethylasesA bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary eliminationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• CAS: 2230788-64-2
• Molecular Formula: C32H49N5O8S -+ xHCl
• Linear Formula: C32H49N5O8S -+ xHCl
• Quantity: 50 mg
• Synonym: tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate; H2N-PEG4-CH2CH2COOtBu; H2N-dPEG(4)-CO-OtBu
• Molecular Weight (g/mol): 663.83 (free base basis) g/mol