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Cayman Chemical AmInopeptIdase NCD13CTRm 100uL

Supplier: Cayman Chemical 32329100 UL

A 5-HT2C receptor antagonist binds to 5-HT2C receptors (Ki 3.8 nM for the recombinant human receptor) and is selective for 5-HT2C receptors over 5-HT2A and 5-HT2B receptors (Kis 1122.02 and 812.83 nM respectively) as well as a panel of additional neurotransmitter receptors and ion channels (Kis ≥316.23 nM for all) inhibits 5-HT-induced increases in the extracellular media acidification rate of CHO-K1 cells expressing human 5-HT2C receptors (pA2 8.1) increases food intake and weight gain in rats at 2 mg/kg increases the time spent in the light compartment in the light-dark exploration test in mice at 2 mg/kg reduces prepulse inhibition of the startle reflex in mice at 1 mg/kg
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