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Medchemexpress LLC Aminopterin (4-aminofolic acid) | 54-62-6 | 98.7% | C19H20N8O5 | 100 MG
Supplier: Medchemexpress LLC HY14518100MG
Aminopterin (4-Aminofolic acid) is a 4-amino derivative of folic acid and acts as a folic acid antagonist. It catalyzes the reduction of folic acid to tetrahydrofolic acid and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. This compound exhibits anticancer and immunosuppressive activities and is utilized in the treatment of pediatric leukemia.
- Folic acid antagonist
- Catalyzes reduction of folic acid to tetrahydrofolic acid
- Competitively inhibits dihydrofolate reductase (DHFR)
- Anticancer activity
- Immunosuppressive activity
- Used in the treatment of pediatric leukemia
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