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Medchemexpress LLC Aminopterin | 54-62-6 | 98.7% | C19H20N8O5 | 50 MG
Supplier: Medchemexpress LLC HY1451850MG
Aminopterin, also known as 4-Aminofolic acid, is a powerful folic acid antagonist. It operates by catalyzing the reduction of folic acid to tetrahydrofolic acid and competitively inhibits dihydrofolate reductase (DHFR) with a high affinity (Ki of 3.7 pM). This compound is recognized for its significant anticancer and immunosuppressive activities, making it a valuable agent in medical applications, particularly in the treatment of pediatric leukemia.
- Acts as a folic acid antagonist
- Competitively inhibits dihydrofolate reductase (DHFR)
- Exhibits anticancer properties
- Possesses immunosuppressive activities
- Used in the treatment of pediatric leukemia
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