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Medchemexpress LLC Aminopterin | 54-62-6 | C19H20N8O5 | 25 MG
Supplier: Medchemexpress LLC 25MGHY14518
Aminopterin, also known as 4-Aminofolic acid, is a folic acid antagonist and a 4-amino derivative of folic acid. It functions by catalyzing the reduction of folic acid to tetrahydrofolic acid and competitively inhibiting dihydrofolate reductase (DHFR) with a Kᵢ of 3.7 pM. This compound exhibits both anticancer and immunosuppressive activities, making it useful in the treatment of pediatric leukemia.
- Folic acid antagonist
- Inhibits dihydrofolate reductase (DHFR)
- Exhibits anticancer activity
- Exhibits immunosuppressive activity
- Used for pediatric leukemia treatment
- IC50 value of 4.4 nM against CCRF-CEM cells
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