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Cayman Chemical AmIsulprIde 50mg
Supplier: Cayman Chemical 1461950 MG
A dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively); an antagonist of 5-HT receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively); selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all); increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively); increases the levels of dopamine and DOPAC in rat striatum and nucleus accumbens at 10 mg/kg i.p.; decreases immobility time in the forced swim test in rats, as well as increases stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress
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