Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Amitriptyline-d6 hydrochloride | 203645-63-0 | 99.9% | 1 MG
Supplier: Medchemexpress LLC HYB0527AS1MG
Amitriptyline-d6 hydrochloride is the deuterium-labeled version of Amitriptyline hydrochloride, an orally active tricyclic antidepressant (TCA). It primarily works by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), which increases the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. It also acts as an agonist at α2A and TrkA/TrkB receptors, contributing to analgesic and neurotrophic effects by inhibiting cell apoptosis.
- Increases concentrations of 5-hydroxytryptamine and norepinephrine in synaptic cleft
- Contributes to analgesic and neurotrophic effects
- Reduces inflammation, angiogenesis, and fibrosis
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can influence pharmacokinetic and metabolic profiles of drugs
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?