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Medchemexpress LLC Amitriptyline hydrochloride | 549-18-8 | 99.9% | 5 G
Supplier: Medchemexpress LLC HYB0527A5G
Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). It primarily exerts its antidepressant effect by blocking SERT and NET, which increases the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. It also acts as an agonist at α2A and TrkA/TrkB receptors, providing analgesic and neurotrophic activities. Amitriptyline hydrochloride can reduce inflammation, angiogenesis, and fibrosis.
- Orally active tricyclic antidepressant (TCA)
- Blocks SERT and NET, increasing 5-HT and NE concentrations
- Agonist at α2A and TrkA/TrkB receptors
- Provides analgesic and neurotrophic activities
- Can reduce inflammation, angiogenesis, and fibrosis
- Binds to DAT and antagonizes muscarinic, H1, and adrenergic α1 receptors
- Can block sodium channels and hERG potassium channel
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