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Apexbio Technology LLC AMN 082 dihydrochloride 97075-46-2 25mg
Supplier: Apexbio Technology LLC B703425
AMN 082 dihydrochloride (CAS 97075-46-2) is a selective allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7) a class C G protein-coupled receptor widely expressed in the nervous system In vitro AMN 082 activates human mGluR7 with an EC50 of 64 nM and induces receptor internalization in isolated hippocampal neurons at concentrations of 0 5 1 M increasing internalization to nearly threefold of control levels AMN 082 binds at a site distinct from the orthosteric glutamate pocket and its activity is not blocked by conventional competitive antagonists In vivo it crosses the blood-brain barrier and modulates stress hormone levels in wild-type but not mGluR7 knockout animals This compound is utilized for investigating mGluR7-mediated synaptic plasticity neuroprotection and stress-related neurological processes
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