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Apexbio Technology LLC Amphotericin B 1397-89-3 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B18855.1

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Amphotericin B is a polyene antifungal antibiotic derived from Streptomyces nodosus It exerts its antifungal action primarily by binding sterols in fungal membranes forming pores that disrupt membrane integrity This binding induces altered ion permeability permitting movement of small ions including potassium and sodium across the membrane Additionally Amphotericin B stimulates inflammatory cytokine release in immune cells through interaction with Toll-like receptor 2 (TLR2) and CD14-dependent pathways Amphotericin B is used in biomedical research to investigate fungal infection mechanisms immune signaling events mediated by TLR pathways and prion-related disorders Its antifungal activity exhibits an IC50 range from 0 028 to 0 290 g/ml in vitro

Catalog No. 50-000-62281


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