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Thermo Scientific™ Human AMPK A1/B1/G1, GST Tag, His Tag Recombinant Protein

Catalog No. PV4672
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PV4672 10 μg
PR8376C 100 μg
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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Full Length.

AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P54619, Q13131, Q9Y478
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with 50% glycerol, 0.02% Triton X-100, 2mM DTT, 0.5mM EDTA, 150mM NaCl and no preservative; pH 7.5
Gene ID (Entrez) 5562, 5564, 5571
Molecular Weight (g/mol) 90.8-57.8-41.7 kDa
Name Human AMPK A1/B1/G1, GST Tag, His Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias AMPK alpha 1/beta 1/gamma 1; AMPK alpha1/beta1/gamma1
Common Name AMPK alpha-1/beta-1/gamma-1
Gene Symbol PRKAA1, PRKAB1, PRKAG1
KinaseFamily CAMKL Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag, His-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Ser⁄Thr Kinases: CAMK Group
Shipping Condition Dry Ice
System Compatibility LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Tag Position GST (N-Terminal)⁄GST (N-Terminal)⁄His (N-Terminal)
Target Entry AMPK (A1/B1/G1)
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Full Length
Form Liquid
Protein Subtype Serine/Threonine Kinases
Research Category Signal Transduction
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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