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STEMCELL Technologies GSK621, Size: 5 mg
Supplier: STEMCELL Technologies 1000266
GSK621 is a specific agonist of AMP-activated protein kinase (AMPK; Sujobert et al.)CANCER RESEARCH· Increases AMPKα T172 phosphorylation, a marker of AMPK activation, in acute myeloid leukemia (AML) cells and primary AML samples (Sujobert et al.).· Displays selective cytotoxicity (IC₅₀ = 13 - 30 μM) by activating autophagy via the eIF2ɑ signaling pathway independent of mTORC1 activation in AML cell lines but not in normal hematopoietic progenitor cells (Sujobert et al.).· Inhibits human melanoma cell survival and proliferation (Chen et al.).
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WARNING: Cancer - www.P65Warnings.ca.gov
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