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Apexbio Technology LLC Amsacrine 51264-14-3 1g
Supplier: Apexbio Technology LLC B13021000
Amsacrine (CAS 51264-14-3) also known as m-AMSA is a small-molecule inhibitor of DNA topoisomerase II It is widely used as an antineoplastic agent in biomedical research particularly for investigating the treatment of lymphomas and acute leukemias Amsacrine exhibits cytotoxic effects across various cancer cell lines with reported IC50 values of 190 2 27 4 ng/ml 46 1 3 9 ng/ml and 22 6 3 1 ng/ml in HT1376 RT112 and RT4 bladder cancer cells and 11 8 2 0 ng/ml 5 0 0 4 ng/ml and 11 7 1 5 ng/ml in the 833K Susa and GH testicular cancer cell lines respectively Testicular cancer cell lines display greater sensitivity to Amsacrine-induced inhibition than bladder cancer cell lines This compound is valuable for studying DNA damage mechanisms and the cellular response to topoisomerase II inhibition
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