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Apexbio Technology LLC Amsacrine hydrochloride 54301-15-4 1g
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Supplier:  Apexbio Technology LLC B13031000

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Amsacrine hydrochloride (CAS 54301-15-4) also known as m-AMSA is a small molecule inhibitor of DNA topoisomerase II By interfering with the religation step of the topoisomerase II catalytic cycle it induces DNA strand breaks and disrupts DNA replication and transcription In vitro studies have shown that Amsacrine hydrochloride exhibits cytotoxicity against various cancer cell lines including bladder (HT1376 RT112 RT4) and testicular (833K Susa GH) cancer cells with IC50 values ranging from 5 0 to 190 2 ng/ml Testicular cancer cell lines display greater sensitivity to this agent compared to bladder cancer cell lines Amsacrine hydrochloride is utilized in research exploring DNA damage mechanisms and antineoplastic drug responses

Catalog No. 50-000-92380


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