CPC Scientific H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-OH (acetate salt) 1MG

Supplier:  CPC Scientific AMYD047A

Peptide substrate that corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, henceforth referred to as the "Swedish "mutation. The peptide has been used for assaying cleavage at leucine-aspartate by cathespin G and chymotrypsin, whereas neither cathepsin B, D, nor L generated any products. ONE-LETTER SEQUENCE: SEVNLDAEFMOLECULAR FORMULA: C44H66N10O18MOLECULAR WEIGHT:1023.07STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [150234-52-9], SYNONYMS: (Asn,Leu)-Amyloid β/A4 Protein Precursor (667-675)RESEARCH AREA: Alzheimer's DiseaseREFERENCES: M. Citron et al., Nature, 360, 672 (1992); M. Mullan et al., Nature Gen., 1, 345 (1992); S.R. Sahasrabudhe et al., J. Biol. Chem., 268, 16699 (1993)

Catalog No. 50-210-8705