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CPC Scientific H-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH (trifluoroacetate salt) 1MG
Supplier: CPC Scientific AMYD049A
This peptide is the C-terminal fragment of amyloid precursor protein (APP) also known as C31. It is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid beta-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid beta-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.ONE-LETTER SEQUENCE: AAVTPEERHLSKMQQNGYENPTYKFFEQMQNMOLECULAR FORMULA: C162H243N45O52S2MOLECULAR WEIGHT:3717.12STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [1802086-24-3], RESEARCH AREA: Alzheimer's DiseaseREFERENCES: D.C.Lu et al., Nat. Med., 6, 397 (2000); C.Dumanchin-Njock et al., J
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