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CPC Scientific H-Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys-OH (trifluoroacetate salt) 1MG
Supplier: CPC Scientific AMYD048B
This peptide comprises a Cu2+-binding site. Binding of Cu2+ to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu2+ to Cu+ by Amyloid beta/A4 Protein Precursor may enhance the production of hydroxyl radicals which in turn may contribute to neurodegeneration in Alzheimer's disease.ONE-LETTER SEQUENCE: FLHQERMDVCETHLHWHTVAKMOLECULAR FORMULA: C116H173N35O31S2MOLECULAR WEIGHT:2618STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [315229-44-8], RESEARCH AREA: Alzheimer's DiseaseREFERENCES: G.Multhaup et al., Science, 271, 1406 (1996)
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