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Medchemexpress LLC Anagrelide hydrochloride | 58579-51-4 | MFCD01720337 | 99.4% | 1 ML
Supplier: Medchemexpress LLC HYB0523A10MM/1ML
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) that inhibits platelet aggregation and bone marrow megakaryocytopoiesis. It has been shown to decrease gastrointestinal stromal tumor (GIST) cell proliferation and promote apoptosis in vitro. This imidazoquinazoline derivative acts as a platelet-lowering agent and exhibits antithrombopoietic action.
- Potent inhibitor of phosphodiesterase type III (PDE3) with an IC50 of 36 nM.
- Inhibits platelet aggregation.
- Inhibits bone marrow megakaryocytopoiesis.
- Decreases gastrointestinal stromal tumor (GIST) cell proliferation.
- Promotes apoptosis in vitro.
- Potently inhibits the development of marrow megakaryocytes (IC50=26 nM).
- Induces a cytotoxic effect in the GIST882 cell line (IC50=16 nM).
- Inhibits or reduces tumor growth in GIST2B, GIST9, and GIST882 models in vivo.
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