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Medchemexpress LLC Anatabine Dicitrate | 99.03% | 544.46 | 100 MG
Supplier: Medchemexpress LLC HY19918A100MG
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It acts as a potent α4β2 nAChR agonist and inhibits NF-κB activation, thereby lowering amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP).
- Possesses anti-inflammatory effects
- Shows potential for treating neurodegenerative disorders
- Inhibits p65 NF-κB phosphorylation
- Prevents increase in BACE-1 mRNA levels
- Inhibits Aβ1-40 and Aβ1-42 in 7W CHO cells
- Lowers brain soluble Aβ1-40 and Aβ1-42 levels in a transgenic mouse model of Alzheimer's disease
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