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AdipoGen Ang-2 mAb blockAngy-2-1
Supplier: AdipoGen AG27B0016PFC500
Recombinant Antibody. Recognizes human and mouse angiopoietin-2. Does not detect human angiopoietin-1. Species cross-reactivity Human, Mouse. Clone Angy-2-1. Isotype Mouse IgG2blambda. Applications ELISA, FUNC Blocking. Host CHO cells. Liquid. In PBS containing 10% glycerol. Angiopoietin-1 Ang-1 and Angiopoietin-2 Ang-2 are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
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