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Medchemexpress LLC Angelic acid | 565-63-9 | MFCD00002654 | 5 MG
Supplier: Medchemexpress LLC HYN69295MG
Angelic acid is a ferroptosis inducer that targets NRF2 degradation. It binds to the NRF2 protein, promoting its degradation through the ubiquitination-proteasome pathway. This action mitigates the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation, leading to the induction of ferroptosis in tumor cells.
- Purity: 99.20%
- Molecular weight: 100.12
- Molecular formula: C5H8O2
- Appears as a white to off-white solid
- Enhances accumulation of intracellular reactive oxygen species
- Upregulates ferroptosis-related markers such as CHAC1 and PTGS2
- Synergizes with other ferroptosis inducers to boost anti-tumor effects
- Scavenges UVA-induced reactive oxygen species
- Inhibits skin fibroblast senescence and prevents extracellular matrix degradation
- Contributes to wound healing and has sedative activity
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