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Apexbio Technology LLC Angiotensin III (human, mouse) 13602-53-4 5mg
Supplier: Apexbio Technology LLC A10435
Angiotensin III (human mouse) [CAS 13602-53-4] is a hexapeptide (Arg-Val-Tyr-Ile-His-Pro-Phe) produced by N-terminal cleavage of angiotensin II via angiotensinase activity in erythrocytes and tissues Within the renin-angiotensin-aldosterone system (RAAS) angiotensin III mediates approximately 40% of the pressor activity of angiotensin II but retains full aldosterone-stimulating capability Experimental studies reveal that exogenous angiotensin III induces aldosterone secretion and suppresses renin release paralleling the effects of angiotensin II Additionally in rodent brain models angiotensin III elicits pressor and dipsogenic responses Angiotensin III interacts with both AT1 and AT2 receptor subtypes with relative specificity for AT2 This peptide serves as a valuable tool to elucidate RAAS function and receptor signaling in cardiovascular and neuroendocrine research
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