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AdipoGen ANGPTL3 FLD h rec
Supplier: AdipoGen AG40A0071YC050
Recombinant Protein. Fibrinogen-like domain of human ANGPTL3 aa 224-460 is fused at the N-terminus to a FLAG -tag. Source/Host HEK 293 cells. Endotoxin <0.01EU/µg purified protein LAL test. Lyophilized. Contains PBS. ANGPTL3 Angiopoietin-like protein 3 regulates angiogenesis and also directly regulates lipid, glucose and energy metabolism. Angiopoietin-like 3 ANGPTL3 is a regulator of plasma triglyceride TRG levels due to its inhibitory action on the activity of lipoprotein lipase LPL. ANGPTL3 induces angiogenesis by binding to integrin alphavbeta3. ANGPTL3 is predominantly produced in the liver and can therefore be classified as a hepatokine. In the human plasma, ANGPTL3 is cleaved to released two fragments a N-terminal coiled-coil domain-containing fragment aa17-207 important for inhibiting the lipolysis of triglyceride and the C-terminal fibrinogen-like domain-containing fragment aa208-460.
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