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AdipoGen ANGPTL4 human pAb
Supplier: AdipoGen AG25A0038C100
Polyclonal Antibody. Recognizes human ANGPTL4. Detects a band of ~35kDa and 62kDa by Western blot. Source Rabbit. Applications ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. ANGPTL4 mainly expressed in endothelial cells hypoxia-induced. Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain FLD. Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase LPL converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion.
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