Anhydrotetracycline hydrochloride

Description

Anhydrotetracycline hydrochloride, CAS # 13803-65-1, is a tetracycline derivative showing antibacterial activity commonly used to control tetracycline-dependent gene expression systems in bacteria. | CAS: 13803-65-1 | C22H23ClN2O6 | 446.88 g/mol

Anhydrotetracycline hydrochloride acts as a useful effector of tetracycline-dependent gene expression in bacterial expression systems.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Anhydrotetracycline hydrochloride is a degradation product derived from tetracycline hydrochloride. It acts as an effector of tetracycline-dependent gene expression in bacterial expression systems. In this system the transcription of genes is reversibly turned on/off in the presence of several compounds including, anhydrotetracycline hydrochloride.
• This compound poorly binds to the 30S ribosomal subunit compared with its precursor, tetracycline.

Applications
• Anhydrotetracycline hydrochloride is commonly used in all fields of biology for control of transcription or translation processes
• This compound has been used in laboratory experiments and shows lower antibacterial activity against Escherichia coli compared with tetracycline.

Specifications

Chemical Identifiers

• CAS: 13803-65-1
• Molecular Formula: C22H23ClN2O6
• Molecular Weight (g/mol): 446.88
• MDL Number: MFCD00151453
• InChI Key: FFZXKJVSZDKEMY-XGRJIHFXNA-N
• PubChem CID: 54710409
• IUPAC Name: hydrogen (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-11,12a-dihydroxy-6-methyl-1,2,3,4,4a,5,12,12a-octahydrotetracene-1,3,12-trione chloride
• SMILES: [H+].[Cl-].CN(C)C1C2CC3=C(C(O)=C4C=CC=CC4=C3C)C(=O)C2(O)C(=O)\C(=C(\N)O)C1=O

• Type: Anhydrotetracycline Hydrochloride
• Physical Form: Crystalline Solid
• Melting Point: 220°C to 223°C
• Color: Yellow
• Quantity: 10 mg
• Sensitivity: Moisture sensitive
• Beilstein: 4228856
• Solubility Information: Soluble in ethanol, DMSO, or DMF
• Formula Weight: 462.88
• Chemical Name or Material: Anhydrotetracycline hydrochloride

Safety and Handling

Hazard Category	H319-H361d
Precautionary Statement	P201-P202-P264b-P280i-P281-P305+P351+P338-P308+P313-P501c
RTECSNumber	QI7860000
TSCA	No
storageNote1	-30° to -10°C
Recommended Storage	Store at -20°C; Store under Argon

SDS

RUO – Research Use Only