Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
List Biological Laboratories Inc Anthrax Edema Factor (EF), Recombinant, Mutant S447N from B. anthracis, 0.5 mg
Supplier: List Biological Laboratories Inc 173B
Since 1978, List Labs products are unsurpassed in quality, consistency, and reliability for the success of your research and development projects! Three proteins are collectively known as anthrax toxin: protective antigen (PA, 83 kDa), lethal factor (LF, 90 kDa) and edema factor (EF, 89 kDa). These proteins play a key role in the pathogenesis of anthrax. EF and LF have enzymatic functions associated with their carboxyl terminals, but require PA to achieve their biological effects. Edema factoris a calmodulin-dependent adenylate cyclase.19 After cell entry, EF is activated when complexed with calmodulin, creating excess amounts of cellular cyclic-AMP. The increase in cyclic-AMP upsets water homeostasis and disrupts the intracellular signaling pathways. It is responsible for the swelling in cutaneous anthrax infections. Edema factor is produced recombinantly in the native host. This mutant has a Ser to Asn substitution located at position 447 decreasing adenylatecyclase activity
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?