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Apexbio Technology LLC ANTI-EGFR PANITUMUMAB-5mg
Supplier: Apexbio Technology LLC F14125
Anti-ERBB1/EGFR/HER1 Antibody (Panitumumab) (CAS No 339177-26-3) is a monoclonal antibody used in oncology research targeting the epidermal growth factor receptor (EGFR) contributing to the inhibition of cancer cell proliferation Originating from recombinant DNA technology it binds specifically to EGFR blocking the activation of the receptor s intracellular kinase domain which is crucial in pathways such as MAPK and PI3K/AKT known for their role in cell growth and survival In vitro Panitumumab exhibits activity in the nanomolar range demonstrating its efficacy in inhibiting tumor growth It is typically applied in cell line studies such as A431 and HER1/EGFR-expressing transfected models and is employed in animal studies to evaluate anti-tumor activity in xenograft models Additionally it serves as a tool in drug screening for the development of EGFR-targeted therapies Experimental concentrations typically depend on the specific research design
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