Anti-F3/Factor III/Tissue Factor/CD142 Antibody (Tisotumab) (CAS No 1418628-81-5) is utilized in the biomedical research field to study hemostasis and thrombosis mechanisms Originating from engineered antibodies it primarily targets tissue factor (TF) a key initiator in the coagulation cascade By binding to TF Tisotumab effectively interrupts the interaction with factor VIIa inhibiting downstream signaling pathways involved in blood coagulation and angiogenesis In vitro activity is often observed in the nanomolar to low micromolar range indicating its potent efficacy It is widely applied in various research models including cell-based assays and animal studies to explore tumor progression and metastatic processes as well as to evaluate potential therapeutic interventions in drug screening programs Experimental concentrations typically depend on the specific research design ensuring adaptability across diverse experimental setups