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Leinco Technologies Inc Anti-Human CD16 (FcγRIII) In Vivo GOLD; Clone 3G8; Isotype: Mouse IgG1 κ
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Supplier:  Leinco Technologies Inc C285825 MG

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Specificity: Clone 3G8 recognizes an epitope on Human CD16. Antigen Distribution: CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts. Background: CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. Applications: (IHC (Frozen), FC, IP, B) 3G8 has been reported to interact with the FcγRIIa and FcγRIIIb receptors causing neutrophil activation and aggregation. 3G8 stimulates NK cell proliferation and blocks neutrophil phagocytosis. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Catalog No. 50-190-6017


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