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Leinco Technologies Inc Anti-Human CD8 (T8, Leu2) In Vivo GOLD; Clone UCHT-4; Isotype: Mouse IgG2a
Supplier: Leinco Technologies Inc C3665.0 MG
Specificity: Clone UCHT-4 recognizes Human CD8. Antigen Distribution: CD8 is expressed on blood lymphocytes, a subset of NK cells, and thymocytes. Persons with HIV exhibit increased levels of CD8+ lymphocytes. Background: CD8 is part of the Ig superfamily that expresses primarily as CD8a homodimers. CD8a is a 32-34 kD type I glycoprotein that can also form heterodimers with CD8b. CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition. Applications: (FC, WB) UCHT-4 may be used in studies of immunoregulation and T-lymphocyte mediated suppression, autoimmune disorders, immunodeficiency states and acute lymphoblastic leukemia and lymphoma. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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