Leinco Technologies Inc Anti-Human HLA-DR (MHC class II, HLA-DR Monomorphic) In Vivo GOLD; Clone L243; Isotype: Mouse IgG2a

Supplier:  Leinco Technologies Inc H2611.0 MG

Specificity: Clone L243 recognizes human class II major histocompatibility complex. Antigen Distribution: HLA-DR is present on B-lymphocytes, activated T-lymphocytes, NK lymphocytes, monocytes, macrophages, human progenitor cells, B-cell lymphomas, and dendritic cells. Background: HLA-DR is a heterodimeric transmembrane glycoprotein comprised of two subunits: a 36 kD alpha (heavy) chain and a 27 kD Beta (light) chain. HLA-DR is vital for efficient peptide presentation to CD4+ T cells. It does not cross-react with HLA-DP and HLA-DQ. Applications: (WB, B) Clone L243 binds a conformational epitope on HLA-DRα which depends on the correct folding of the αβ heterodimer. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Catalog No. 50-190-6335