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Bio X Cell Antibody, Mouse CD209b, Clone 22D1, 5 MG
Supplier: Bio X Cell BE0220R005MG
The 22D1 monoclonal antibody reacts with mouse CD209b, also known as SIGN-R1. CD209b is a 37 kDa type II transmembrane C-type lectin receptor. It is expressed on the surface of splenic marginal zone and lymph node medullary macrophages and serves as a marker for these cells. CD209b is involved in the innate immune response, binding to and initiating the uptake of various microorganisms by recognizing high-mannose-containing glycoproteins on their envelopes. The 22D1 antibody has been reported to block CD209b in vivo.
- Monoclonal antibody 22D1 reacts with mouse CD209b (SIGN-R1).
- CD209b is a 37 kDa type II transmembrane C-type lectin receptor.
- Expressed on splenic marginal zone and lymph node medullary macrophages.
- Involved in innate immune response.
- Binds to and initiates uptake of microorganisms via high-mannose-containing glycoproteins.
- Antibody 22D1 blocks CD209b in vivo.
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