Bio X Cell Monoclonal Antibody, Mouse PD-1 (CD279), Clone RMP1-14

Supplier:  Bio X Cell BE0146R025MG

The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1), also known as CD279. PD-1 is a 50-55 kDa cell surface receptor expressed on CD4 and CD8 thymocytes, as well as activated T and B lymphocytes and myeloid cells. PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. This antibody blocks the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1, making it suitable for in vivo blocking applications.

• Isotype: rat IgG2a, κ
• Immunogen: Syrian Hamster BKH cells transfected with mouse PD-1 cDNA
• Reported applications: in vivo blocking of PD-1/PD-L signaling, in vitro Organoids/Organ-on-Chip
• Formulation: PBS, pH 7.0, contains no stabilizers or preservatives
• Endotoxin: ≤1 EU/mg (≤0.001 EU/μg) determined by LAL assay
• Purity: ≥95% determined by SDS-PAGE
• Sterility: 0.2 μm filtration
• Molecular weight: 150 kDa
• Purification:

Catalog No. 50-562-456