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Leinco Technologies Inc Anti-Mouse IFNAR1 (CD118, Ifar, Ifnar, Ifrc, IFN-a receptor, Interferon-α/β receptor α chain) In Vivo GOLD; Clone MAR1-5A3; Isotype: Mouse IgG1
Supplier: Leinco Technologies Inc I401100 MG
Specificity: Clone MAR1-5A3 recognizes mouse IFNAR1. Antigen Distribution: IFNAR1 & IFNAR2 are coexpressed on most cells. Background: IFNAR1 & IFNAR2 make up the heterodimeric receptor that binds all type I IFNs, which includes IFN α & β. Type I IFNs are a family of cytokines that have been shown to promote anti-viral, anti-microbial, anti-tumor & autoimmune responses In vivo. Applications: (WB, FA) MAR1-5A3 blocks Type I IFN receptor signaling as well as both In vitro & In vivo type I interferon biological responses. This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1. Leinco’s In vivo GOLDTM & In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques & are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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