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Leinco Technologies Inc Anti-Mouse CD11a (LFA-1α) In Vivo GOLD; Clone FD441.8; Isotype: Rat IgG2b
Supplier: Leinco Technologies Inc C303100 MG
Specificity: Clone FD441.8 recognizes an epitope on mouse CD11a. Antigen Distribution: CD11a is present on thymocytes, blood lymphocytes, bone marrow cells and certain lymphoma and macrophage-like cell lines. Background: LFA-1α and CD18 combine to form LFA-1, a 180 kDa glycoprotein and a member of the integrin family. Through interaction with ICAM-1 (CD54) and ICAM-2 (CD102), LFA-1 mediates heterotypic and homotypic intracellular adhesions. LFA-1 participates in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells. Applications: (WB, FA) Clone FD441.8 inhibits ConA-facilitated lysis, but does not affect PHA-facilitated lysis. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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