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Leinco Technologies Inc Anti-Mouse 4-1BB (CD137, TNFRSF9, 4-1BB, CD137 Antigen, T-Cell Antigen, ILA) In Vivo PLATINUM; Clone 3H3; Isotype: Rat IgG2a
Supplier: Leinco Technologies Inc C28355.0 MG
Specificity: Clone 3H3 recognizes an epitope on mouse 4-1BB. Antigen Distribution: 4-1BB is expressed on activated B cells and T cells, macrophages, and dendritic cells. Background: 4-1BB (CD137) is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. 4-1BB signal regulates CD28 co-stimulation in the targeted subset cells to favor Th1 development and maintain long-term cell growth. 4-1BB controls the duration, DC-T interaction, and immunogenicity. Applications: (WB, FA) Clone 3H3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling In vivo. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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