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Leinco Technologies Inc Anti-Mouse CTLA-4 (CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56) In Vivo PLATINUM; Clone 9D9; Isotype: Mouse IgG2b
Supplier: Leinco Technologies Inc C28561.0 MG
Specificity: Clone 9D9 recognizes an epitope on mouse CTLA-4. Antigen Distribution: CTLA-4 is expressed on activated T and B lymphocytes. Background: CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 negatively regulates cell-mediated immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. This antigen is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. Application: (WB, FA) Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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