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Leinco Technologies Inc Anti-Mouse CD154 (Bp50, TNFRSF5, CD40) In Vivo PLATINUM; Clone FGK4.5; Isotype: Rat IgG2a
Supplier: Leinco Technologies Inc F119550 MG
Specificity: Clone FGK4.5 recognizes an epitope on mouse CD40. Antigen Distribution: CD40 is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, and endothelial cells. Background: CD40 is a 48 kD type I transmembrane glycoprotein and part of the TNFR superfamily. CD40 is involved in the proliferation and differentiation of B cells and is critical for Ig class switching. The membrane-anchored CD40L is expressed almost exclusively on activated CD4+ T lymphocytes. CD40L is thought to play a part in the pathogenesis of some diseases including immunodeficiency with hyper-IgM and Alzheimer Disease. Applications: (WB, FA) Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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