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Leinco Technologies Inc Anti-Mouse CD44 (Hermes, Pgp1, H-CAM, HUTCH, Ly-24) In Vivo GOLD; Clone IM7; Isotype: Rat IgG2b
Supplier: Leinco Technologies Inc C3821.0 MG
Specificity: IM7 recognizes an epitope common to alloantigens and all isoforms of CD44 that is located between amino acids 145 and 186. Antigen Distribution: CD44 is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells in addition to B-cells, monocytes, macrophages and certain subsets of thymocytes and peripheral T-cells. Mice with the Ly-24.1 allotype have high densities of CD44+ T-cells. Background: CD44 is a 80-95 kD glycoprotein. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low/mid levels to high levels. Applications: (IP, WB) IM7 antibody has been shown to neutralize CD44 In vivo. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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