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Leinco Technologies Inc Anti-Mouse IFNß (HDb-4A7) In Vivo PLATINUM; Clone HDß-4A7; Isotype: Mouse IgG2a
Supplier: Leinco Technologies Inc B6591.0 MG
Specificity: Clone HDß-4A7 binds specifically to murine IFNß. Antigen distribution: IFNß is expressed on fibroblasts and epithelial cells. Background: IFN-β is a 26-35 kD glycoprotein type I IFN and is involved in the innate immune system, being released non-specifically during the early stage of infection in response to stimuli such as viruses or bacterial components. IFN-β is the therapeutic target for treating multiple sclerosis. Applictions: (WB, B, FA) HDb-4A7 binds both recombinant and natural forms of IFNb. Clone HDß-4A7blocks In vivo IFNb leading to increased the lethality of mice infected with West Nile Virus, like susceptibility of IFNb-/- mice. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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