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Leinco Technologies Inc Anti-Mouse TNFR1(CD120α, CD120a, TNF R Type I/p55) In Vivo GOLD; Clone 55R-170; Isotype: Armenian Hamster IgG
Supplier: Leinco Technologies Inc T950100 MG
Specificity: Clone 55R-170 recognizes mouse CD120α. Antigen Distribution: CD120α is expressed in various cell types at low levels. Background: CD120α is a 55kD Type I transmembrane protein receptor that binds both TNF-α and TNF-β (LT-α). In association with TRADD and RIP, the receptor crosslinking induced by TNF-α or TNF-β trimers is vital for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. Applications: (IP, WB) Clone 55R-170 has been reported to block In vitro and In vivo receptor signaling initiated by ligand binding. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
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